教員紹介

所属	農学部生物機能科学科農学研究科
学位	博士（農学）
専門	分子生物学、ゲノム生物学、細菌学
コメント	最新ゲノム解析技術を改良し、病原菌における新規抗菌剤の効き方や、遺伝子の新しい働きを解明する研究に取り組んでいます。また、薬の副作用を軽減するアプタマー医薬品開発を推進しています。
リサーチマップリンク	https://researchmap.jp/read0137572

比較ゲノム, 情報伝達, 遺伝子発現調節, Comparative genomics, Signal transduction, Gene regulation

Development of conjugation-mediated versatile site-specific single-copy luciferase fusion system , Akinori Kato , The Journal of General and Applied Microbiology , 2024年3月 , 査読有り
Isolation and draft genome sequence of Enterobacter asburiae strain i6 amenable to genetic manipulation , Akinori Kato , Journal of Genomics , 12 , 26-34 , 2024年1月 , 査読有り
Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control. , Yoshitani K; Ishii E; Taniguchi K; Sugimoto H; Shiro Y; Akiyama Y; Kato A; Utsumi R; Eguchi Y , Bioscience, biotechnology, and biochemistry , 83 , 4 , 684-694 , 2019年4月 , 査読有り

細菌におけるリポ多糖の修飾の状態とシグナル伝達系との相互フィードバック制御 , 加藤明宣; Eduardo A. Groisman , ライフサイエンス新着論文レビュー , 47 , 6 , 897 , 908 , 2012年9月
概要：Gram-negative bacteria often modify their lipopolysaccharide (LPS), thereby increasing resistance to antimicrobial agents and avoidance of the host immune system. However, it is unclear how bacteria adjust the levels and activities of LPS-modifying enzymes in response to the modification status of their LPS. We now address this question by investigating the major regulator of LPS modifications in Salmonella enterica. We report that the PmrA/PmrB system controls expression of a membrane peptide that inhibits the activity of LpxT, an enzyme responsible for increasing the LPS negative charge. LpxT's inhibition and the PmrA-dependent incorporation of positively charged L-4-aminoarabinose into the LPS decrease Fe3+ binding to the bacterial cell. Because Fe3+ is an activating ligand for the sensor PmrB, transcription of PmrA-dependent LPS-modifying genes is reduced. This mechanism enables bacteria to sense their cell surface by its effect on the availability of an inducing signal for the system regulating cell-surface modifications.
Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor , A Kato, EA Groisman , Faculty Opinions , 2004年9月