Researchers

HAYASHI Hidetoshi

HAYASHI Hidetoshi
Professor/Senior Staff
Faculty Department of Medicine / Graduate School of Medical Sciences
Researchmap https://researchmap.jp/hayashi_h

Education and Career

Education

  • 1997/04 - 2003/03 , Osaka University, Faculty of Medicine,
  • 2009/04 - 2012/03 , Kindai University, Faculty of Medicine,

Academic & Professional Experience

  • Apr. 2023 - Today , Kindai University, Faculty of Medicine Department of Medical Oncology Professor
  • Apr. 2022 - Today , Kindai University, Faculty of Medicine Department of Medical Oncology 特命准教授
  • Apr. 2020 - Mar. 2022 , 近畿大学医学部 内科学腫瘍内科 講師
  • Oct. 2015 - Mar. 2020 , Kindai university hospital Department of Medical Oncology Lecturer
  • Apr. 2015 - Sep. 2015 , Kindai university hospital Department of Medical Oncology Assistant professor
  • Apr. 2013 - Mar. 2015 , Kishiwada City Hospital Department of Medical Oncology Director
  • Apr. 2009 - Mar. 2013 , Kindai university hospital Department of Medical Oncology assistant professor
  • Apr. 2006 - Mar. 2009 , Kurashiki Central Hospital Respiratory Medicine Medical Staff
  • Apr. 2003 - Mar. 2006 , Sumitomo Hospital General Medicine Resident

Research Activities

Research Areas

  • Life sciences, Tumor diagnostics and therapeutics

Research Interests

Cancer of Unknown Primary, Lung Cancer, Gene analysis, medical oncology, immune checkpoint inhibitor

Published Papers

  1. Immune-related gene expression profiling and alectinib efficacy for patients with ALK-Rearranged non-small cell lung cancer: exploratory analysis of a prospective observational study.
    Takashi Kurosaki; Shinichiro Suzuki; Yasutaka Watanabe; Hirotsugu Kenmotsu; Shoichi Itoh; Masafumi Yamaguchi; Ayako Shiono; Takuji Suzuki; Toshihide Yokoyama; Yukihiro Toi; Hisashi Tanaka; Masahide Oki; Takeshi Tsuda; Eiki Ichihara; Koichi Azuma; Hiroshi Tanaka; Ryo Arai; Ken Uchibori; Eisaku Miyauchi; Ryohei Katayama; Hidetoshi Hayashi
    Lung cancer (Amsterdam, Netherlands)  216  , 109416-109416, Jun. 2026 
  2. Quantitative evaluation of healthcare information provided to patients with thoracic malignancies: patient satisfaction survey of the Japan Lung Cancer Society
    Takayuki Takahama; Hidefumi Shimizu; Kenichi Yoshimura; Hidehito Horinouchi; Hiroyasu Kaneda; Kiyotaka Watanabe; Hiromi Aono; Keiko Tanaka; Seiki Hasegawa; Tomohiro Osawa; Hidetoshi Hayashi; Takeshi Yoshida; Yasuhisa Ohde; Tomoki Kimura; Mitsutoshi Akiho; Hatoe Sakamoto; Mayumi Ito; Kazuo Hasegawa; Koji Onishi; Jiichiro Sasaki; Satoshi Oizumi; Tetsuya Mitsudomi; Akihiko Gemma; Toshiyuki Sawa
    International Journal of Clinical Oncology  27, May. 2026 
  3. Constitutive EGFR Activation Induced by PTPRR Downregulation Confers Resistance to KRAS Inhibitors.
    Hiroaki Kanemura; Toshiyuki Takehara; Osamu Maenishi; Shuta Tomida; Natsumi Iwawaki; Kei Kunimasa; Tomohiro Nakayama; Satomi Watanabe; Shinichiro Suzuki; Kazuko Sakai; Koichi Azuma; Keita Kudo; Kazuto Nishio; Kazuhiko Nakagawa; Hidetoshi Hayashi; Takeshi Teramura; Kimio Yonesaka
    Cancer research communications  6  (4)  , 728-741, 1, Apr. 2026 

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Conference Activities & Talks

  1. Prognostic impact of EMT-related genes on post-operative prognosis in hepatocellular carcinoma. , 永井 知行; 荒尾 徳三; 松本 和子; 藤田 至彦; 林 秀敏; 木村 英晴; 萩原 智; 櫻井 俊治; 上嶋 一臣; 土師 誠二; 工藤 正俊; 西尾 和人 , AACR 103rd Annual Meeting 2011 , Mar. 2012
  2. 進行肺腺癌を対象としたゲフィチニブ／S-1併用療法第１層臨床試験 , 清田 秀美; 岡本 勇; 田中 薫; 林 秀敏; 寺嶋応顕; 東 公一; 武田真幸; 米阪 仁雄; 藤阪 保仁; 鶴谷 純司; 宮﨑 昌樹; 佐藤 太郎; 倉田 宝保; 中川 和彦 , 第51回日本肺癌学会総会 , Nov. 2010
  3. 進行肺腺癌を対象としたゲフェチニブ／S-1 併用療法第１相臨床試験 , 清田 秀美; 岡本 勇; 谷﨑 潤子; 文田 壮一; 岡本 邦男; 牧村 ちひろ; 竹澤 健; 田中 薫; 林 秀敏; 岡本 渉; 寺嶋応顕; 東 公一; 金田裕靖; 武田真幸; 上田 眞也; 米阪 仁雄; 藤阪 保仁; 鶴谷 純司; 宮﨑 昌樹; 佐藤 太郎; 倉田 宝保; 中川 和彦 , 第92回日本肺癌学会関西支部会 , Jul. 2010

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MISC

  1. 胃癌におけるCLDN18.2中等度発現の腫瘍内不均一性に関する研究(Intratumoral Heterogeneity of Intermediate CLDN18.2 Expression in Gastric Cancer) , 川中 雄介; 稲垣 千晶; 大倉 將生; 三谷 誠一郎; 白石 直樹; 坂井 和子; 西尾 和人; 木村 豊; 千葉 康敬; 若狭 朋子; 川上 尚人; 林 秀敏 , 日本胃癌学会総会記事 , 98回 , 922 , 922 , Mar. 2026
  2. PTPRRのダウンレギュレーションにより誘導されるEGFRの恒常的活性化はKRAS阻害薬耐性を付与する(Constitutive activation of EGFR induced by downregulation of PTPRR confers resistance to KRAS inhibitors) , 金村 宙昌; 竹原 俊幸; 前西 修; 冨田 秀太; 岩脇 菜摘; 國政 啓; 中山 智裕; 渡邊 諭美; 鈴木 慎一郎; 坂井 和子; 東 公一; 西尾 和人; 中川 和彦; 林 秀敏; 米阪 仁雄 , 肺癌 , 65 , 5 , 394 , 394 , Nov. 2025
  3. Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer , Kimio Yonesaka; Takashi Kurosaki; Junko Tanizaki; Hisato Kawakami; Kaoru Tanaka; Osamu Maenishi; Shiki Takamura; Kazuko Sakai; Yasutaka Chiba; Takeshi Teramura; Hiroki Goto; Eri Otsuka; Hiroaki Okida; Masanori Funabashi; Yuuri Hashimoto; Kenji Hirotani; Yasuki Kamai; Takashi Kagari; Kazuto Nishio; Kazuhiro Kakimi; Hidetoshi Hayashi , CANCER RESEARCH , 85 , 8 , 15, Apr. 2025

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Patents

  1. 免疫チェックポイント阻害剤の奏効性の判定を補助する方法、試薬キット、装置及びコンピュータプログラム , 本庶 佑, 茶本 健司, 林 秀敏, 中川 和彦, 後藤 恵, 宇賀 均
  2. 免疫チェックポイント阻害剤の奏効性の判定を補助する方法、試薬キット、装置及びコンピュータプログラム , 本庶 佑, 茶本 健司, 林 秀敏, 中川 和彦, 後藤 恵, 宇賀 均 , 特許第7251738号

Awards & Honors

  1. Dec. 2022, 日本肺癌学会, 篠井・河合賞
  2. Jul. 2015, 日本臨床腫瘍学会, 日本臨床腫瘍学会奨励賞
  3. Jun. 2008, 西日本がん研究機構, 西日本がん研究機構賞

Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of Next-Generation Cancer Immunotherapy through Comprehensive Elucidation of TMB-Independent Non-Canonical Neoantigens , Kindai University
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Validation study of a model for estimating the primary organ of cancer of unknown primary by methylation analysis of circulating tumor DNA , Kindai University
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Validation study of a model to estimate the primary organ of cancer of unknown primary , Kindai University

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