Researchers

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MOTOZONO Chihiro
Research associate
Faculty Department of Medicine
Researchmap https://researchmap.jp/immunol1

Research Activities

Research Areas

  • Life sciences, Virology
  • Life sciences, Immunology

Published Papers

  1. Repeated mRNA vaccination and breakthrough infection reveal durable dominance but diminishing recall of vaccine-induced CD8⁺ T-cell clones.
    Peng Xu; Satoshi Ueha; Hiroyasu Aoki; Masahiro Kitabatake; Chen Mingyu; Shigeyuki Shichino; Atsushi Hara; Noriko Ouji-Sageshima; Toshihiro Ito; Chihiro Motozono; Kouji Matsushima
    International immunology  16, Jan. 2026 
  2. Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope.
    Yoshihiko Goto; You Min Ahn; Mako Toyoda; Hiroshi Hamana; Yan Jin; Yoshiki Aritsu; Takeshi Nakama; Yuka Tajima; Janesha C Maddumage; Huanyu Li; Mizuki Kitamatsu; Hiroyuki Kishi; Akiko Yonekawa; Dhilshan Jayasinghe; Nobuyuki Shimono; Yoji Nagasaki; Rumi Minami; Takashi Toya; Noritaka Sekiya; Yusuke Tomita; Demetra S M Chatzileontiadou; Hirotomo Nakata; So Nakagawa; Takuro Sakagami; Takamasa Ueno; Stephanie Gras; Chihiro Motozono
    Nature communications  16  (1)  , 8062-8062, 28, Aug. 2025 
  3. A probiotic bacterium modulates antitumor γδ T-cell responses in lung cancer
    Yoshihiko Goto; Garry Dolton; Hannah Thomas; Théo Morin; Yuka Tajima; Kosuke Imamura; Shinya Sakata; Kentaro Oka; Atsushi Hayashi; Motomichi Takahashi; Takamasa Ueno; Takuro Sakagami; Yusuke Tomita; Andrew K. Sewell; Chihiro Motozono
    19, Jul. 2025 

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MISC

  1. Cross-reactivity of HLA-A*24:02-restricted T-cell receptors towards SARS-CoV-2 mutations , 仲摩健; 浜名洋; LI Huanyu; 後藤由比古; 有津由樹; 豊田真子; TAN Toong Seng; 北松瑞生; 宇高恵子; 岸裕幸; 上野貴将; 本園千尋 , 日本ウイルス学会学術集会プログラム・予稿集(Web) , 70th , 2023
  2. Evaluation of T cell antigen recognition for peptides introduced unnatural amino acids , 有津由樹; 北松瑞生; TAN Toong Seng; 上野貴将; 本園千尋 , 日本化学会春季年会講演予稿集(Web) , 102nd , 2022
  3. Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection , C. Motozono; S. Tsuji-Kawahara; S. Takamura; M. Miyazawa , EUROPEAN JOURNAL OF IMMUNOLOGY , 46 , 817 , 817 , Aug. 2016

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Awards & Honors

  1. 2023, 日本エイズ学会, ECC山口メモリアルエイズ研究奨励賞
  2. 2022, 熊本大学, 令和4年度 熊本大学研究業績表彰者

Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivity , Kumamoto University
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivity , Kumamoto University
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of HLA-independent T cell receptor-T cell therapy for innovative immunological cancer therapy , University of Toyama

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