Researchers

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Faculty	Department of Medicine / Graduate School of Medical Sciences
Researchmap	https://researchmap.jp/ryuichiog

1998/04 - 2002/03 , Osaka University, Faculty of Science,
2002/04 - 2004/03 , Osaka University, Graduate School, Division of Natural Science,
2004/04 - 2007/09 , Osaka University, Graduate School of Science,

Apr. 2026 - Today , 近畿大学医学部薬理学教室主任教授
Mar. 2021 - Mar. 2026 , 大阪大学大学院医学系研究科生体システム薬理学准教授
Sep. 2020 - Mar. 2026 , 大阪大学先導的学際研究機構生命医科学融合フロンティア研究部門（兼任）
Apr. 2016 - Feb. 2021 , 大阪大学大学院医学系研究科学部内講師
Apr. 2009 - Feb. 2021 , 大阪大学大学院医学系研究科生体システム薬理学助教
Mar. 2009 - Mar. 2009 , 大阪大学大学院医学系研究科生体システム薬理学博士研究員
Feb. 2008 - Feb. 2009 , Groningen University University Medical Center Groningen Visiting research felllow
Oct. 2007 - Feb. 2009 , 大阪大学大学院理学研究科生体膜機能学研究室博士研究員

トランスポーター, タンパク質局在化機構, 細胞極性, シグナル情報伝達, アミノ酸トランスポーター, Na+/H+交換輸送体, 非特異性多発性小腸潰瘍症, シスチン尿症, 角質細胞間脂質, 表皮バリア, 脂質代謝

L-type amino acid transporter 1 deficiency delays intestinal tissue repair in dextran sulfate sodium-induced colitis
Yunlong Sui; Norihiro Okamoto; Namiko Hoshi; Yuta Inoue; Yuna Ku; Misaki Agawa; Hirotaka Nakamura; Haruka Miyazaki; Daisuke Watanabe; Makoto Ooi; Yoshihiko Yano; Ryuichi Ohgaki; Yoshikatsu Kanai; Hui Yang; Yuzo Kodama
International Immunopharmacology 172 , 116138-116138, Mar. 2026 , Refereed
Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
Kou Nishikubo; Ryuichi Ohgaki; Hiroki Okanishi; Minhui Xu; Yoshikatsu Kanai
Cancer & Metabolism 13 (1) 2, Dec. 2025 , Refereed
Structural basis of anticancer drug recognition and amino acid transport by LAT1
Yongchan Lee; Chunhuan Jin; Ryuichi Ohgaki; Minhui Xu; Satoshi Ogasawara; Rangana Warshamanage; Keitaro Yamashita; Garib Murshudov; Osamu Nureki; Takeshi Murata; Yoshikatsu Kanai
Nature Communications 16 (1) , 1635-, 14, Feb. 2025 , Refereed

LAT1 Inhibition-induced cell cycle arrest via p38 MAPK mediated cyclin D1 downregulation in cancer cells , Xinyu Zhou; Ryuichi Ohgaki; Chunhuan Jin; Minhui Xu; Hiroki Okanishi; Yoshikatsu Kanai , The 84th Annual Meeting of the Japanese Cancer Association , 27, Sep. 2025
Upregulation of ATF4 on LAT1 inhibition in pancreatic cancer cell lines , Yu Ma; Suguru Okuda; Hiroki Okanishi; Minhui Xu; Chunhuan Jin; Ryuichi Ohgaki; Yoshikatsu Kanai , The 84th Annual Meeting of the Japanese Cancer Association , 25, Sep. 2025
Potentiation of PD-1 blockade efficacy via T cell activation induced by inhibition of amino acid transporter LAT1 , Minhui Xu; Xinyu Zhou; Chunhuan Jin; Hiroki Okanishi; Ryuichi Ohgaki; Yoshikatsu Kanai , The 84th Annual Meeting of the Japanese Cancer Association , 25, Sep. 2025

アミノ酸トランスポーター阻害薬によるアミノ酸恒常性の破綻：抗腫瘍効果の分子基盤 , 大垣隆一 , BIO Clinica , 41 , 2 , 92 , 95 , Feb. 2026
アミノ酸トランスポーター阻害薬によるがん治療 -研究の展開と解明が進むユニークな抗腫瘍効果の発現機序- , 大垣隆一 , 日本応用酵素協会誌 , 56 , 21 , 28 , Mar. 2022
Cell surface pH imaging using poly(ethylene glycol)-phospholipid: its potential as the core structure of membrane anchored-probes , 大垣隆一; 寺村裕治; 林大智; 永森收志; 永森收志; 高井まどか; 金井好克 , 日本薬理学雑誌 , 153 , 6 , 254 , 260 , Jun. 2019

Dec. 2022, 公益財団法人日本膵臓病研究財団, 令和4年度膵臓病研究奨励賞
Sep. 2012, 第3回分子腎臓フォーラム優秀賞
Sep. 2006, Biological Science/Institute for Protein Research, Graduate School of Science, Osaka University, The 21st COE Program Research Assistant Progress Report Best Poster Award