Researchers
- OKADA Hitoshi
- Professor/Senior Staff
Faculty | Department of Medicine / Graduate School of Medical Sciences |
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Researchmap | https://researchmap.jp/hiokada |
Education and Career
Education
- 1981/04 - 1987/03 , Tohoku University, School of Medicine,
- 1991/04 - 1995/03 , Tohoku University, 大学院,
Academic & Professional Experience
- Apr. 2014 - Today , Kindai University, Faculty of Medicine Dept. of Biochemistry Professor
- Jul. 2012 - Mar. 2014 , University of Toronto Dept. of Medical Biophysics Associate Professor
- May. 2005 - Mar. 2014 , Campbell Family Institute for Breast Cancer Research Staff Scientist
- May. 2005 - Mar. 2014 , Ontario Cancer Institute Scientist
- Nov. 2005 - Jun. 2012 , University of Toronto Dept. of Medical Biophysics Assistant Professor
- Mar. 1999 - Apr. 2005 , Ontario Cancer Institute 博士研究員
- Feb. 1998 - Feb. 1999 , Columbia University 博士研究員
- Apr. 1995 - Jan. 1998 , 財団法人癌研究会癌研究所 細胞生物部 嘱託研究員
Research Activities
Research Areas
- Life sciences, Laboratory animal science
- Life sciences, Medical biochemistry
- Life sciences, Tumor biology
- Life sciences, Pathobiochemistry
Research Interests
Aging, Metabolism, DNA damage response, Apoptosis, Epigenome, Tumor biology
Published Papers
-
Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer.
Suman Dash; Takeshi Ueda; Akiyoshi Komuro; Masahiko Honda; Ryoichi Sugisawa; Hitoshi Okada
Cell death & disease 15 (2) , 131-131, 12, Feb. 2024 -
MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance.
Suman Dash; Takeshi Ueda; Akiyoshi Komuro; Hisayuki Amano; Masahiko Honda; Masahito Kawazu; Hitoshi Okada
Molecular cancer research : MCR 21 (5) , 444-457, 9, Feb. 2023 -
KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility.
Takeshi Ueda; Akinori Kanai; Akiyoshi Komuro; Hisayuki Amano; Kazushige Ota; Masahiko Honda; Masahito Kawazu; Hitoshi Okada
FASEB bioAdvances 3 (12) , 1020-1033, Dec. 2021 , Refereed
Books etc
- ジーンターゲティングの実際 , 岡田 斉; 野田哲生 , 実験医学 , 1996
Conference Activities & Talks
- エピジェネティクスから考える環境因子と肥満 , 岡田 斉 , 第18回 日本抗加齢医学会総会プログラム , May. 2018
- Role of histone demethylases in breast cancer development , Hitoshi Okada , The 76th Annual Meeting of the Japanese Cancer Association , 29, Sep. 2017
- マウスモデルを用いたDNA損傷応答制御による 治療関連白血病発症抑制の試み , 岡田 斉 , 第21回日本がん分子標的治療学会学術集会 , 15, Jun. 2017
MISC
- 骨髄系腫瘍におけるNEDD化酵素の腫瘍抑制的な役割 , 上田 健; Dash Suman; 本多 賢彦; 古室 暁義; 岡田 斉 , 日本生化学会大会プログラム・講演要旨集 , 96回 , [1P , 479] , Oct. 2023
- 網羅的CRISPRライブラリースクリーニングによるIFNγ-PD-L1経路制御因子の同定 , 岡田 斉; Dash Suman; 本多 賢彦; 古室 暁義; 上田 健 , 日本生化学会大会プログラム・講演要旨集 , 96回 , [1P , 493] , Oct. 2023
- Gemcitabine-resistant PDAC cells with DCK deficiency show upregulated expression of MYC and glutamine target genes. , DASH Suman; 上田健; 古室暁義; 岡田斉 , 日本癌学会学術総会抄録集(Web) , 82nd , 2023
Research Grants & Projects
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 代謝ストレスにより誘導される新規肝がんモデルの作製と機能解析 , 近畿大学
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), TGFbによるSirt1の制御と炎症性腸疾患の抑制機構の解明 , Kindai University
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), ヒト-細菌叢間 化学コミュニケーションの理解と炎症性腸疾患・がん・がん免疫 , Kindai University