Researchers
- SUGIURA Reiko
- Professor/Director
| Faculty | Department of Pharmaceutical Sciences / Graduate School of Medicine / Pharmaceutical Research and Technology Institute |
|---|---|
| Researchmap | https://researchmap.jp/read0052052 |
Education and Career
Academic & Professional Experience
- Oct. 2020 - Today , 近畿大学大学院 薬学研究科長
- Apr. 2004 - Mar. 2025 , Kindai University Faculty of Pharmacy 教授
- Oct. 2012 - Sep. 2020 , Kindai University Faculty of Pharmacy, Department of Pharmaceutical Sciences 科長
Research Activities
Research Areas
- Life sciences, Pharmaceuticals - health and biochemistry
- Life sciences, Cell biology
- Life sciences, Applied molecular and cellular biology
- Life sciences, Pharmacology
Research Interests
Disordered protein, ストレス応答, 細胞死, ゲノム薬理学, ケミカルバイオロジー, 液ー液相分離, ストレス顆粒, カルシニューリン, 分裂酵母, 免疫制御, MAPキナーゼ, 細胞内輸送, RNA結合タンパク質, 分子遺伝学, タンパク質リン酸化, シグナル伝達, RNAバイオロジー, 転写制御, モデル生物, ゲノム創薬
Published Papers
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Alpha-Synuclein Fails to Form Aggregates in Endocytosis-Defective Fission Yeast Strains, ∆ myo1 and ∆ end4.
Teruaki Takasaki; Ryuga Yamada; Yoshitaka Sugimoto; Reiko Sugiura
microPublication biology 2025 2025 -
Rapamycin Abrogates Aggregation of Human α-Synuclein Expressed in Fission Yeast via an Autophagy-Independent Mechanism.
Yoshitaka Sugimoto; Teruaki Takasaki; Ryuga Yamada; Ryo Kurosaki; Tomonari Yamane; Reiko Sugiura
Genes to cells : devoted to molecular & cellular mechanisms 30 (1) , e13185-, Jan. 2025 -
Characterization of a valproic acid-sensitive mutant allele of the Golgi GDP-mannose transmembrane transporter Vrg4 in Schizosaccharomyces pombe
Takasaki T.; Yamada M.; Ikeda H.; Fang Y.; Sugiura R.
MicroPubl Biol. 2024 Aug. 2024 , Refereed
Books etc
- 図解腫瘍薬学 , 川西, 正祐; 賀川, 義之; 大井, 一弥 , がん特異的シグナル伝達 , がん特異的シグナル伝達 , 南山堂 , Jul. 2020
- 酵母の生命科学と生物工学 : 産業応用から基礎科学へ (DOJIN BIOSCIENCE SERIES) , 原島 俊; 高木 博史 , 化学同人 , 7, Aug. 2013
- 岩波 生物学辞典 第5版 , 巌佐 庸; 倉谷 滋; 斎藤 成也; 塚谷 裕一 , 岩波書店 , 27, Feb. 2013
Conference Activities & Talks
- 新規抗がん剤候補化合物ACA-28耐性骨肉腫細胞に対してACA-28のがん細胞増殖阻害効果を増強する方法ー新規抗がん剤候補化合物ACA-28耐性機構と抗がん作用増強におけるNRF-2の役割ー , 泉 大地; 高崎 輝恒; 杉浦 麗子 , 第146回日本薬理学会近畿部会 , 30, Nov. 2024
- mTOR阻害剤Rapamycinはパーキンソン病モデル分裂酵母細胞においてヒトα-synucleinの凝集形成を抑制する , 山田 琉雅; 杉本 恵崇; 髙崎 輝恒; 杉浦 麗子 , 第146回日本薬理学会近畿部会 , 30, Nov. 2024
- 分裂酵母プロテインキナーゼCのストレス顆粒移行の制御機構とMAPKシグナル経路活性化の関わり , 秦しほみ; 冨本尚史; 高崎輝恒; 杉浦麗子 , 第146回日本薬理学会近畿部会 , 30, Nov. 2024
MISC
- Valproic acid impacts aggregation and toxicity associated with α-Synuclein overproduction~Crosstalk between α-synuclein and membrane traffic and glycosylation~ , 山田南; 杉本恵崇; 黒崎亮; 高崎輝恒; 佐藤亮介; 杉浦麗子 , 日本分子生物学会年会プログラム・要旨集(Web) , 46th , 2023
- Relationship between phosphorylation of a KH-type RNA-binding protein Rnc1 and its translocation to stress granules , 吉田展康; 川崎有紀; 原信樹; 佐藤亮介; 高崎輝恒; 杉浦麗子 , 日本分子生物学会年会プログラム・要旨集(Web) , 46th , 2023
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Role of the DNA damage response protein BRAT1 in the ROS mediated induction of cell death induced by a novel anticancer compound ACAGT-007a
, 田中達也; 佐藤亮介; 高崎輝恒; 杉浦麗子; 杉浦麗子 , 日本分子生物学会年会プログラム・要旨集(Web) , 46th , 2-B-SS12-6 , 2023
Summary:We have previously identified an anti-cancer compound ACA-28 and its lead compound ACAGT-007a (GT-7) as novel regulators of ERK MAPK signaling using our chemical genetic screen. ACA-28 and GT-7 have unique properties to suppress cell proliferation and induce cell death by further activating ERK in cancer cells with high ERK activity, such as melanoma and pancreatic cancer cells. However, the detailed mechanism of cell death induction by these compounds has not been elucidated. To determine protein targets of ACA-28 relevant for apoptosis induction, we searched for molecules that can bind to ACA-28 and found that BRCA1-associated ATM activator1 (BRAT1), which acts as a DNA damage response protein (DDR protein) upon DNA damage, is a candidate binding protein for ACA-28. We also established a melanoma cell line with acquired resistance to GT-7 (referred to as ACA-R-SK). Interestingly, the expression levels of BRAT1 were significantly higher in ACA-R-SK cells as compared with the original SK-MEL-28 cells. Furthermore, the addition of GT-7 markedly decreased the expression of BRAT1 in both cell lines. Knockdown of BRAT1 by introducing BRAT1 siRNA into the ACA-28 resistant ACA-R-SK cells enhanced cell death induction by GT-7. These results suggest that the down-regulation of BRAT1 may play a key role in the mechanism of cell death induction by GT-7. In this presentation, I will discuss the possible mechanisms of BRAT1 downregulation by GT-7 and the role of BRAT1 in the induction of cell death by GT-7. References 1) Satoh et al. Identification of ACA-28, a 1’ -acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells. Genes Cells 2017, 22, 608-618 2) Khandakar et al. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells 2022,11,702
Patents
- 抗腫瘍剤 , 杉浦 麗子, 村岡 修, 筒井 望, 喜多 綾子, 久能 樹 , 特許第6047309号
- キャビコール類縁体化合物およびMAPキナーゼシグナル伝達阻害薬 , 杉浦 麗子, 萬瀬 貴昭, 村岡 修, 吉川 雅之, 安原 智久 , 特許第5774049号
- 容器の栓体 , 石渡 俊二, 多賀 淳, 藤田 秀樹, 西田 升三, 喜多 綾子, 杉浦 麗子 , 特許第5716064号
Awards & Honors
- Jun. 2018, 神戸大学, 優秀研究者賞
- Mar. 2004, 上原記念生命科学振興財団, 上原記念生命科学振興財団 研究奨励賞
- 2001, 日本薬理学会学術奨励賞
Research Grants & Projects
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Mechanisms of cancer-specific apoptosis induction targeting ERK hyperactivation , Kindai University
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Regulatory mechanisms of MAPK signaling and its application to chemicalgenomics , Kinki University
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Comprehensive promotion of research on RNA program