Researchers

YAMADA Takahiro

YAMADA Takahiro
Research associate
Faculty Department of Computational Systems Biology
Researchmap https://researchmap.jp/Takahiro-YAMADA

Education and Career

Education

  • 2006/04 - 2009/03 , 兵庫県立川西明峰高等学校,
  • 2011/04 - 2015/03 , Kindai University, Faculty of Biology-Oriented Science and Technology,
  • 2015/04 - 2017/03 , Kindai University, Graduate School of Biology-Oriented Science and Technology,
  • 2017/04 - 2020/03 , Kindai University, Graduate School of Biology-Oriented Science and Technology,

Academic & Professional Experience

  • Apr. 2026 - Today , Kindai University Faculty of Biology-Oriented Science and Technology Department of Computational Systems Biology Assistant Professor
  • Oct. 2025 - Mar. 2026 , Department of Radiology, Kindai University of Medicine 医局秘書（定時職員）
  • Apr. 2025 - Sep. 2025 , Minami Sakai Hospital Radiology assistant
  • Apr. 2025 - Sep. 2025 , Kindai University of Medicine Department of Radiology research assistant
  • Apr. 2020 - Mar. 2025 , Division of Positron Emission Tomography Institute of Advanced Clinical Medicine, Kindai University. research associate
  • Apr. 2019 - Mar. 2020 , 地方独立行政法人 東京都健康長寿医療センター研究所 神経画像研究チーム 研究生

Research Activities

Research Areas

  • Informatics, Biological, health, and medical informatics
  • Life sciences, Biomedical engineering
  • Life sciences, Radiology

Research Interests

医用画像処理・解析, 核医学動態解析, 放射線医学, 薬物速度論, 認知症, Alzheimer's disease, dementia with Lewy bodies, Amyloid-PET, FDG-PET, Tau-PET, MRI, CT, AI

Published Papers

  1. Synthesis of amyloid images using generative adversarial network from 2- dimensional 18 F-FDG images and evaluation in clinical use
    Misa Honda; Takahiro Yamada; Shogo Watanabe; Aya Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Katsuhiro Mikami; Kohei Hanaoka; Hayato Kaida; Hisashi Handa; Kazunari Ishii; Yuichi Kimura
    Journal of Nuclear Medicine Technology  (in press)  Jan. 2026  , Refereed
  2. Off-target binding of 18F-MK-6240 tau PET imaging demonstrated by high spatial resolution dedicated brain PET scanner
    Kazunari Ishii; Takahiro Yamada; Kohei Hanaoka; Hayato Kaida; Yasuyuki Kojita; Atsushi Kono; Kenji Ishii; Takashi Kato; Akinori Nakamura
    Annals of Nuclear Medicine  (in press)  Jan. 2026  , Refereed
  3. A Robust Residual 3DCNN Model for Prediction of Amyloid-β Positivity by using FDG PET
    Ilya Ardakani; Takahiro Yamada; Sayaka Iwano; Ángel Muñoz-González; Sunil Kumar Maurya; Kazunari Ishii; for the Alzheimer’s Disease
    Clinical Nuclear Medicine  50  (8)  , 707-713, Aug. 2025  , Refereed

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Conference Activities & Talks

  1. Synthesizing amyloid PET images from FDG-PET images by generative AI with 2.5D training , Misa Honda; Takahiro Yamada; Syougo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Katsuhito Mikami; Kohei Hanaoka; Hayato Kaida; Hisashi Handa; Kazunari Ishii; Yuichi Kimura , 第65回日本核医学会学術総会 , 14, Nov. 2025
  2. CutMixを用いたがん骨転移患者CT像上の骨領域抽出精度改善の検討 , 井澤 康樹; 根本 充貴; 甲斐田 勇人; 北島 一宏; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 石井 一成 , 日本生体医工学シンポジウム2025 , 12, Sep. 2025
  3. Multiple instance learning を活用したFDG-PET/CT 像上の胸部領域病変検出の初期検討 , 佐原 詢之佑; 根本 充貴; 甲斐田 勇人; 北島 一宏; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 石井 一成 , 日本生体医工学シンポジウム2025 , 12, Sep. 2025

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MISC

  1. [Proceedings] 2.5-dimensional multi-task learning for accurate detection of adrenal metastasis on abdominal FDGPET/CT images , Mitsutaka Nemoto; Kohei Yoshida; Hayato Kaida; Yuichi Kimura; Takashi Nagaoka; Katsuhiro Mikami; Takahiro Yamada; Kohei Hanaoka; Tatsuya Tsuchitani; Kazuhiro Kitajima; Kazunari Ishii , Computer Assisted Radiology and Surgery Proceedings of the 39th International Congress and Exhibition , 20 , Suppl 1 , S106 , S107 , May. 2025
  2. [Bulletin] Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes , Koji Sugimoto; Takahiro Yamada; Atsushi Kono; SungWoon Im; Kazunari Ishii , Acta Medica Kindai University , 49 , 1 , 1 , 6 , Jun. 2024
    Summary:Purpose: Our earlier investigation assessed the correlation between regional accumulations of a tau positron emission tomography (PET) tracer (THK5351) and cognitive dysfunction in the Alzheimer's disease (AD) continuum brain. We reported significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and MiniMental State Examination (MMSE)/Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) scores. Herein, we explored the relationship between these variables in non-AD pathologic brains. Methods: Thirty-one subjects with non-AD pathologic changes (mean age: 64.6±11.3 yrs) underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET. All subjects completed the MMSE (mean±SD score: 27.0±4.1), and 20 subjects (mean age: 63.8±11.9 yrs) also completed the ADAS (9.7±9.3). A voxel-wise statistical analysis using statistical parametric mapping determined the correlations between each subject's FDG and THK imaging results and their MMSE and ADAS scores. Results: The voxel-wise statistical analysis revealed that FDG accumulations in the left temporal cortices were significantly positively correlated with the subjects' MMSE scores and significantly negatively correlated with their ADAS scores. A negative correlation was observed between the subjects' MMSE scores and THK5351 accumulations in the left temporal and medial frontal cortices and the right temporal pole. A positive correlation was observed between the subjects' ADAS scores and THK5351 accumulations in the left temporal cortices and the right anterior temporal lobe. Conclusions: Compared to FDG accumulation, THK5351 accumulations correlated more strongly with neuropsychological test scores in non-AD pathologic brains, likely due to THK5351's affinity for both tau and monoamine oxidase-B. THK5351 measurements may be valuable for clarifying the pathophysiology of non-AD pathologic changes in the brain.
  3. [Proceedings] Surmise of breast density using mammographic X-ray exposure conditions , Yoshiyuki Asai; Mika Yamamuro; Takahiro Yamada; Yuichi Kimura; Kazunari Ishii; Yohan Kondo , 17th International Congress for Radiation Research , Abstract Book , 191 , 192 , Aug. 2023

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Awards & Honors

  1. Jun. 2022, Society of Nuclear Medicine and Molecular Imaging (SNMMI), SNMMI-TS Professional Development Grant Award
  2. Apr. 2018, 日本核医学会, nan
  3. Nov. 2017, 日本核医学会 核医学理工分科会, 第7回核医学画像解析研究会 研究奨励賞

Research Grants & Projects

  1. Japan Society for the Promotion of Science, (KAKENHI) Grants-in-Aid for Scientific Research, non title , Kindai Univ.
  2. 株式会社日本メジフィジックス, 2022年度研究者主導臨床研究支援プログラム研究助成, 脳FDG-PETによる脳アミロイド沈着予測 , 近畿大学
  3. 近畿大学, 近畿大学学内助成（令和3年度オール近大新型コロナウイルス感染症対策支援プロジェクト）, 非COVID-19肺炎の胸部CTの特徴的所見 , 近畿大学

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