教員紹介

前川智弘

前川智弘: 教授/創薬科学科長

所属	薬学部創薬科学科薬学研究科薬学総合研究所
学位	博士（薬学）
専門	医薬品化学
ジャンル	科学・技術/化学
コメント	有機化学を基盤とした医薬品化学に関する研究をしています。医薬品を開発する上で有用な有機化学反応の開発も行っています。
リサーチマップ	https://researchmap.jp/read0198565
メールアドレス	maegawa@phar.kindai.ac.jp

医薬品化学研究室

学歴/経歴

学歴

- 2003年
大阪大学薬学研究科
- 2003年
大阪大学 Graduate School, Division of Pharmaceutical Sciences
- 1998年
名古屋大学工学部
- 1998年
名古屋大学 Faculty of Engineering

経歴

2019年4月 - 現在
近畿大学薬学部医薬品化学研究室教授
2013年4月 - 2019年3月
近畿大学薬学部医薬品化学研究室准教授
2009年1月 - 2013年3月
大阪大学大学院薬学研究科特任准教授
2007年10月 - 2008年12月
岐阜薬科大学薬品化学研究室講師
2007年4月 - 2007年9月
岐阜薬科大学薬品化学研究室助教
2003年4月 - 2007年3月
岐阜薬科大学薬品化学研究室助手

研究活動情報

研究分野

ライフサイエンス, 薬系化学、創薬科学

研究キーワード

環境調和型反応, 複素環, 有機合成化学, catalytic reaction, synthetic organic chemistry

論文

Concise synthetic routes for diphenylacetylene from tetrachloroethylene using Suzuki coupling reaction followed by treatment with n-butyllithium
Yuta Fujiki; Hiyono Suzuki; Junya Kikuzawa; Keiji Nishiwaki; Norihito Kawashita; Junpei Matsuoka; Akira Nakamura; Tomohiro Maegawa; Akiko Kuwabara; Masafumi Kobayashi; Kouichi Matsumoto
Chemistry Letters 53 (6) 2024年6月1日
Elemental Sulfur-Mediated Aromatic Halogenation
Junpei Matsuoka; Yuna Yano; Yuuka Hirose; Koushi Mashiba; Nanako Sawada; Akira Nakamura; Tomohiro Maegawa
The Journal of Organic Chemistry 89 (1) 770-777 2023年12月19日
n-Bu4NI/H2O2-catalyzed mild conversion of hydroxamic acids to carboxylic acids
Akira Nakamura; Jyunya Morimoto; Maho Taniguchi; Haruka Aoyama; Jiadong He; Tomohiro Maegawa
Tetrahedron Letters 126 154656-154656 2023年8月

クライン有機化学問題の解き方 : 日本語版 , Klein, David R.; 伊藤, 喬 , 東京化学同人 , 2020年3月
医薬品構造化学 : 薬の構造と薬理作用の関係を紐解く , 前川, 智弘 , 京都廣川書店 , 2017年3月

MISC

Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine , Reiya Ohta; Nao Matsumoto; Yoshifumi Ueyama; Yuichi Kuboki; Hiroshi Aoyama; Kenichi Murai; Mitsuhiro Arisawa; Tomohiro Maegawa; Hiromichi Fujioka , Journal of Organic Chemistry , 83 , 12 , 6432 , 6443 , 2018年6月15日
概要：© 2018 American Chemical Society. Acetals are the most useful protecting groups for carbonyl functional groups. In addition to the role of protection, they can also be used as synthons of carbonyl functions. Previously, we developed a chemoselective deprotection and nucleophilic substitution of acetals from aldehydes in the presence of ketals. This article describes the highly discriminative and chemoselective transformations of acetals bearing different substitution patterns, different types of acetals, as well as mixed acetals. These reactions can achieve the transformations that cannot be attained by conventional methods, and their results strongly suggest the combination of R3SiOTf/2,4,6-collidine to promote such unprecedented phenomena.
The reaction of acetal-type protective groups in combination with TMSOTf and 2,2 '-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groups , Hiromichi Fujioka; Yutaka Minamitsuji; Ozora Kubo; Kento Senami; Tomohiro Maegawa , TETRAHEDRON , 67 , 16 , 2949 , 2960 , 2011年4月
概要：A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2'-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O. (C) 2011 Elsevier Ltd. All rights reserved.
The reaction of acetal-type protective groups in combination with TMSOTf and 2,2 '-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groups , Hiromichi Fujioka; Yutaka Minamitsuji; Ozora Kubo; Kento Senami; Tomohiro Maegawa , TETRAHEDRON , 67 , 16 , 2949 , 2960 , 2011年4月
概要：A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2'-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O. (C) 2011 Elsevier Ltd. All rights reserved.